Cyclosporin and mitochondrial dysfunction.

results indicate that after the injection of MSH(4-10)DTPA-l “In, radioactivity is eliminated from the blood with a physiological half-life of 0.19 h. This compares with 1 1 h for bisMSH-DTPA injected by the same route IS]. As a consequence of this rapid elimination, tumour radioactivity was well differentiated from the background by 4 h and at this time, the mean tumour/blood ratio was 10.6 f 0.4 and the liver/blood ratio was 3.01 f 0.17 (s.E.M., n = 10) (Fig. I ). These figures are considerably more favourable than those obtained with bisMSH-DTPA (Fig. 1 ) and suggest that short-chain melanotropins may be preferred to bisMSH-DTPA for the targeting of imaging agents to melanomas.